This study says: In conclusion, we have demonstrated that BMJ possess strong efficacy against human pancreatic carcinoma cells without any noticeable side effects. Molecular studies revealed that BMJ activates AMPK in pancreatic carcinoma cells both in vitro and in vivo and induced strong apoptotic death. Considering the short survival and high mortality due to pancreatic cancer, BMJ that is widely consumed as vegetable and for health benefits could have significant translational relevance in managing this deadly malignancy.
Source: Natural News
Potent cytotoxicity against all four pancreatic cancer cell lines tested
Researchers at University of Colorado Cancer Center prepared bitter melon juice by simply purchasing the melons (Chinese variety) from a local grocery store, removing pulp and seeds, then using a household juicer. Solids were removed, and the remaining juice was either tested directly on cell cultures, or freeze dried and ground into a fine powder to be used later for feeding to mice.
When tested against cancer cell cultures, bitter melon juice (diluted to just five percent in water) showed remarkable potency in reducing the viability of all four pancreatic cancer cell lines tested. The viability of AsPC-1and Capan-2 cancer cell lines was reduced by 90 percent, while BxPC-3 and MiaPaCa-2 viability was reduced by 98 percent, after 72 hours treatment. The juice was seen to induce programmed cell death (apoptosis) along several different pathways. More importantly, it also activated AMPK, which indicates that it disrupts the cancer cells’ metabolism of glucose, literally starving them of the sugar they need to survive...continue reading at Natural News
Source: Life Extension
Bitter Melon Juice Reduced Tumor Growth By 60%
Bitter melon is a fruit that grows in Asia, Africa, and the Caribbean. Traditionally it has been used to treat diabetes. This is what spiked the interest of Dr. Rajesh Agarwal, a lead researcher in the Colorado study. He thought bitter melon might treat pancreatic cancer, since Type II diabetes often precedes the disease.
Researchers examined the effect of bitter melon on 4 different lines of pancreatic cancer cells and in mice. Mice were injected with pancreatic tumor cells and were randomly divided into one of two groups. One group received water (control), and the second was given bitter melon juice for six weeks. At the end of the study, the tumors that developed on the mice were dissected, weighed, and analyzed.
The results showed that bitter melon juice inhibited cancer cell proliferation and induced apoptosis (cell death). Tumor growth was inhibited by 60% in the treatment group with no signs of toxicity.1
Bitter Melon Regulates Insulin, Which Fuels Tumor Growth
In addition to treating pancreatic cancer, bitter melon may have the potential to prevent it as well. Bitter melon helps to regulate the secretion of insulin from pancreatic cells.2
Many tumors have insulin receptors which transport glucose to cancer cells, helping them to grow, divide, and multiply. Studies show insulin encourages pancreatic cancer cells to grow in a dose-dependent manner.3
In addition, having diabetes is a risk factor for the disease. Metformin, an insulin-sensitizing drug, has been shown to improve the survival rate in diabetic, pancreatic cancer patients.1
Bitter Melon Combats Other Cancers Too
Further studies show bitter melon displays anti-tumor effects for other cancers including that of the breast, prostate and colon.1
A key mechanism it targets is AMPK (adenosine monophosphate-activated protein kinase), a molecule that regulates cell growth and replication…continue reading at Life Extension
Extract taken from an Asian vegetable may have therapeutic qualities to treat head and neck cancer, a Saint Louis University researcher has found.
Preliminary findings of the research were published in the Public Library of Science One Journal by Ratna Ray, Ph.D. associate professor of pathology at Saint Louis University. Ray found that bitter melon extract, a vegetable commonly used in Indian and Chinese diets, reduces the head and neck cancer cell growth in the animal model.
“We wanted to see the effect of the bitter melon extract treatment on different types of cancer using different model systems,” said Ray, who first tested the extract in breast and prostate cancer cells. “In this study, the bitter melon extract treatment suppressed the head and neck cancer cell growth in the mouse model, reducing the growth of the tumor.”
In a controlled lab setting, Ray found that bitter melon extract regulated several pathways that helped reduce the head and neck cancer cell growth in the animal model. After a period of four weeks, Ray found that the growth and volume of the tumor had reduced...continue reading at ScienceDaily
Where can I get this treatment and more information??
Widely available in food stores.