Cachexia affects 50–80 % of advanced cancer patients, with currently no effective treatments. Cachexia is defined by increased fatigue and loss of muscle function. This results in diminished physical activity, reduced tolerance to anticancer therapies and overall increased death.
Available evidence suggests that chemotherapy (i.e. the use of cytotoxic and anti-proliferative drugs) may play a key role in the development and sustainment of cachexia (Study)
The following can help:
- Melatonin (study)
- Cannabinoids (study)
- Omega 3 Fatty Acids (study)
- Pomegranate (study)
- Supplements containing n-3 polyunsaturated fatty acids (study)
- In cancers where high inflammatory stress is usual, protein rich supplements containing n-3 polyunsaturated fatty acids and high levels of antioxidant vitamins can reverse severe weight loss (study)
Note: The 3 major antioxidant vitamins are beta-carotene, vitamins C and vitamin E.
- Endurance training (study)
- Hydrazine Sulfate (study)
A substance that has been studied as a treatment for cancer and as a treatment for cachexia (body wasting) associated with advanced cancer.
This study states: There is good evidence that hydrazine sulfate inhibits gluconeogenesis. Therefore, it may play a role in reducing the severity of cachexia and in improving the quality of life of cancer patients.
This study says: In 38 patients with glioblastomas Sehydrin (Hydrazine Sulfate) administration resulted in at least tumor stabilization and tumor regression in 27 (71%).
L‐arginine, L‐glutamine, and Hydroxy methyl butyrate
Study Review: …we selected five studies that were suitable for our systematic review.The results of the studies shows that this combination can improve fat free mass, weight and immune function in cachexia and morbid weight loss patients. Supplementation with a combination of Arginine, Glutamine, and HMB [Hydroxy methyl butyrate] may improve cachexia and morbid weight loss in cancer patients.
Since malignant cancer cells metabolise blood sugar into lactic acid, the Coy diet uses very minimal amounts of carbohydrates and sugars. In doing so, the cancer cells are cut off from their main energy supply, glucose, and lose strength, which weakens cancer cells, so that treatments are more effective.
The diet contains foods rich in energy that cannot be used by TKTL1-positive cells. This energy will then be at the disposal of the healthy cells and may prevent the threatening loss of weight.
See more foods info here
This study says: Cancer cachexia and malnutrition are associated with an increased risk of surgical complications and higher toxicity levels of chemotherapy. Quality of life and overall survival of colon cancer patients can improve under early nutritional intervention. L-Carnitine is critical for energy generation by mitochondrial ß-oxidation and was found depleted under chemotherapy. Its oral supplementation can normalize nutritional L-Carnitine deficiency and reduce chemotherapy related side effects. We therefore tested whether oral L-Carnitine supplementation has a clinical benefit in patients with advanced pancreatic cancer and found that L-Carnitine can reduce malnutrition, increase bodyweight and improve body composition.