Balance your Immune System
What is the immune system?
A complex network of cells, tissues, organs, and the substances they make that helps the body fight infections and other diseases. The immune system includes white blood cells and organs and tissues of the lymph system, such as the thymus, spleen, tonsils, lymph nodes, lymph vessels, and bone marrow. – National Cancer Institute
A good immune system can work for or against you!
This 2019 study by Yuexin Liu, MD Anderson Cancer Center looked at the effect pre-existing immune conditions had on cancer. A total of 10,062 PanCanAtlas tumor samples had both gene expression and survival data, covering 32 different cancer types.
The results showed that in the majority of human cancers, higher immune response was significantly associated with better Overall Survival.
The study also demonstrated that in some cancer types higher immune response is significantly associated with worse outcome.
In particular, higher immune responses were significantly correlated with longer Overall Survival in 7 cancer types:
- breast invasive carcinoma,
- cervical squamous cell carcinoma and endocervical adenocarcinoma,
- head and neck squamous cell carcinoma,
- lung adenocarcinoma,
- sarcoma,
- skin cutaneous melanoma
- uterine corpus endometrial carcinoma.
In contrast, higher immune responses were significantly correlated with shorter Overall Survival in four cancer types:
- kidney renal clear cell carcinoma,
- low-grade glioma,
- thymoma,
- uveal melanoma.
Aside from the cancer types mentioned above, the rest of the cancer types did not show significant correlation between immune response and patient Overall Survival.
Conclusions: Immune responses have different impacts on patient outcome in different human cancers.
TNBC and ER-positive/HER2-negative breast cancer.
This 2022 study found that a high immune response in triple negative breast cancer is associated with better survival.
However, survival was negatively correlated with immune activity in ER-positive/HER2-negative breast cancer.
Ways to REDUCE your Immune System Response
In this study, 24 healthy volunteers were divided into two groups – an intervention or control group.
Subjects in the intervention group were trained for 10 d in meditation (third eye meditation), breathing techniques (i.a., cyclic hyperventilation followed by breath retention), and exposure to cold (i.a., immersions in ice cold water).
The control group was not trained. Subsequently, all subjects underwent experimental endotoxemia (i.v. administration of 2 ng/kg Escherichia coli endotoxin). In the intervention group, practicing the learned techniques resulted in intermittent respiratory alkalosis and hypoxia resulting in profoundly increased plasma epinephrine levels.
The study demonstrate that voluntary activation of the sympathetic nervous system results in epinephrine release and subsequent suppression of the innate immune response in humans in vivo. These results could have important implications for the treatment of conditions associated with excessive or persistent inflammation, such as autoimmune diseases.
Ways to BOOST your Immune System Response
Get Daily Physical Exercise
Exercise greatly improves the immune system.
It improves survival rates of some cancer patients by 50 per cent.
Radically Change Your Diet
Certain foods can boost your immune system. Eat a high fibre, high bioactive foods diet, including: Porridge, Beans & Pulses, Fruit and vegetables.
Get Adequate Sleep
Prolonged sleep curtailment produces pro-inflammatory cytokines, best described as chronic low-grade inflammation, and also produce immunodeficiency, which both have detrimental effects on health [study]
Melatonin is a natural hormone produced by your body about an hour after you fall asleep. It helps you sleep more deeply and can improve cancer survival. Available as a supplement.
This study says: Ashwagandha, an herb, has been proven to be safe and effective in improving sleep quality.
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Practice Meditation
This study concluded: across 20 RCTs and more than 1600 participants, we found tentative evidence that mindfulness meditation modulates some select immune parameters in a manner that suggests a more salutogenic immune profile.
Laugh more
People who laugh a lot have stronger immune systems.
This study says that patients with advanced cancer have lower immunity which is further decreased with surgery or chemotherapy. Chemotherapy patients who undertook the Laughter Therapy using the Smile-Sun Methodology during treatment in the hospital showed significantly higher immunity levels.
Have Healthy Sex
Researchers at Wilkes University surveyed 112 subjects about their sexual frequency. They then analyzed their saliva for infection-fighting immunoglobulin A (IgA). Compared with the other groups, those who had sex once or twice a week showed significantly higher IgA levels. Lead researcher Carl Charnetski said “Moderately frequent sex enhances immune function… [ study]
Consume Probiotics
Probiotics, the friendly microflora in our bodies, contribute to the production of useful metabolites with positive effects on the immune system against various diseases such as cancer [Study]
This study found that probiotics C. butyricum and B. subtilis inhibited the proliferation of colorectal cancer cells, …and improved immune homeostasis.
Probiotic sources include sauerkraut, yogurt, kefir, kimchi, tempeh, miso, natto and kombucha.
If you are undergoing treatment, talk to your doctor before taking probiotics because they can be dangerous if you have a severely weakened immune system,
Aromatherapy (Essential Oils)
This study says essential oil from Eucalyptus globulus is able to implement the innate cell-mediated immune response.
This study suggests that EOB [Essential Oil Blend] possesses significant anti-inflammatory and immune modulating properties.
Immune boosting oils include: Tea tree oil, Frankincense (C02 extract), Eucalyptus Globulus. Oils can be applied directly to the skin, inhaled, sprayed in a room or used in a diffuser to purify the air.
Asaigermanium
Experiment ② Asaigermanium activates NK cells: NK cells are an abbreviation for “natural killer cells” and literally means “born killer.” When they recognize invading pathogens or abnormal cells, they start attacking quickly.
Test: Nine healthy people were divided into three groups of three, and each subject intook 25, 50, and 100 mg / kg of Asaigermanium, and the NK cell activity of peripheral blood lymphocytes was measured.
Result: All groups showed that NK cell activity increased one day after ingestion of Asaigermanium, and that activity was maintained for four days thereafter.
Practice Qigong
The results show that Qigong modulates immune cell numbers in human peripheral blood. Qi may stabilize the sympathetic nervous system and thereby induce recruitment and proliferation of immune cells [Study]
This study demonstrates that Taoist qigong is able to exert acute immunomodulatory effects on components of both innate as well as adaptive immune [Study]
Maintain a healthy weight.
Obesity…is known to impair the immune function, altering leucocyte counts as well as cell-mediated immune responses, according to this study.
Prevent Infections
Harvard Medical School offer the following advice:
- You should wash your hands after blowing your nose, coughing, or sneezing; feeding or stroking your pet; or visiting or caring for a sick person.
- Cover your mouth and nose with a tissue when you sneeze or cough,
- Wash and bandage all cuts. Any serious cut or animal or human bite should be examined by a doctor.
Avoid Stress
According to Academy of Nutrition and Dietetics, stress turns on the fight or flight mechanisms, increasing the production of hormones that can raise blood sugar levels and suppress immune function.
Don’t Smoke
Chronic inhalation of cigarette smoke alters a wide range of immunological functions, including innate and adaptive immune responses according to this study published in Nature journal.
Limit sugar intake
According to Biotics Research Corporation, man-made sweeteners like aspartame and HFCS [High Fructose Corn Syrup] can have serious deleterious effects on the immune system, especially on infants, and, as such, should be avoided.
Cut down on alcohol
…alcohol can weaken the immune system and make the body more susceptible to infections, according to the prestigious Cleveland Clinic.
Beware all drugs
Many studies, including one published by Oxford Academic show that drugs (whether legal or not) such as Antibiotics, Proton-pump inhibitors, Opiates, Cocaine, Heroin etc may affect many important components of the complex immune system, either enhancing or occasionally suppressing the function of distinct immune response cells and the factors they produce.
Immune Boosting Vitamins and Supplements
AHCC (Active hexose correlated compound)
AHCC is a natural immune-modulating compound derived from specially-cultured medicinal mushroom which has been clinically shown to strengthen the body’s immune system.
In this study of 269 patients with liver cancers, 113 received AHCC orally after undergoing curative surgery. This group had a significantly longer no recurrence period …and an increased overall survival rate when compared to the control group.
This study found: AHCC has the potential to reduce the severity of neutropenia induced by breast cancer chemotherapy.
AHCC® is manufactured by Amino Up Chemical Co, Ltd (Sapporo, Japan). Here is the web page listing authorised ahcc brands. These are the only brands the company endorse. Here are two options for people in Ireland: Biovea and Amazon
Beta Glucans (mushrooms etc)
Beta-glucan may stimulate the immune system and help kill cancer cells – National Cancer Institute
This study says the effects of b-glucans are beneficial in chemo and radiotherapy induced immunesuppression and depleted hematopoiesis. b–Glucan shows anticarcinogenic activity, prevent oncogenesis and prevent metastasis.
Breuss therapy
Breuss Therapy is a 42-day fast during which you drink an organic juice made of beetroot, carrot, celery root, raw potato and black radish. The Breuss Cancer Juice boosts your immune system to fight cancer naturally. At the same time you cut off the cancer’s food supply and effectively starve tumours through fasting
Carica Papaya
This study says: Recent studies have shown its beneficial effect as an anti-inflammatory agent, for its wound healing properties, antitumour as well as immune-modulatory effects and as an antioxidant.
Study: These findings provide evidence for immunostimulatory and anti-inflammatory actions of Carica Seed Extract.
Study: Recent research on papaya leaf tea extract has demonstrated cancer cell growth inhibition. It appears to boost the production of key signaling molecules called Th1-type cytokines, which help regulate the immune system.
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Coenzyme Q10
Coenzyme Q10 (CoQ10) has a number of important roles in the cell that are required for optimal functioning of the immune system. [study]
This 2021 study showed that CoQ10 supplementation reduced some of the important markers of inflammation…in patients with breast cancer.
This study found an increase in DNA repair enzymes and disappearance of DNA methylation patterns attributes to reduction in tumor burden and may suggest good prognosis and efficacy of the treatment.
The ubiquinol form of coenzyme Q10 is considered more easily absorbed.
Curcumin
There are more than 1,500 studies looking into effects of curcumin on numerous types of cancer.
Curcumin has been shown in the last two decades to be a potent immunomodulatory agent that can modulate the activation of T cells, B cells, macrophages, neutrophils, natural killer cells, and dendritic cells (study)
Echinacea
Study: The herb, Echinacea…has become one of the top-selling herbs of all time. Many of its ingredients are powerful immune system stimulators.
Study: Flavonoids act as an immune-stimulant, they are present in Echinacea…lessen the harmful consequence of radiotherapy and chemotherapy. It also helps the patients in prolonging the survival time with progressive stage of cancer.
Study: Echinacea herbal preparations are primarily used for their immunostimulatory effects…chronic long-term use (>6–8weeks) of Echinacea may be immunosuppressive
Essiac Tea
This study of 510 women with a diagnosis of primary breast cancer found most women were taking Essiac to boost their immune systems or increase their chances of survival. Only 2 women reported minor adverse events, whereas numerous women reported beneficial effects of Essiac.
This study says the formula is now manufactured as Essiac® by Essiac Products in New Brunswick. Here is their website Essiac Products and Facebook page.Here is another source: Ojibwa Tea of Life
Not recommended for brain cancer patients as it may induce swelling which could be life-threateningif it creates too much pressure in the cerebral cavity..
GcMAF
GcMAF is a is a human protein. It acts as a “director” of your immune system. This study concluded that, in addition to its ability to activate tumor killing immune cells, GcMAF has direct anti tumor-forming effects on endothelial cells independent of tissue origin.
This study: Sixteen nonanemic prostate cancer patients received weekly administration of 100 ng of GcMAF. As the MAF precursor activity increased, their serum Nagalase activity decreased…After 14 to 25 weekly administrations of GcMAF (100 ng/week), all 16 patients had very low serum Nagalase levels equivalent to those of healthy control values, indicating that these patients are tumor-free. No recurrence occurred for 7 years.
Ginger Extract
This study says: The health-promoting perspectives of ginger are well known. It can treat a wide range of diseases via immunonutrition and anti-inflammatory responses…
Ginseng
This study: As a well-known herbal immune stimulant, hundredsof studies have extensively reported the anti-cancer or chemopreventive effects of ginseng. The anti-cancer effects of ginseng are mainly through the improvements in cell-mediated immunity consisting of cytotoxic T cells and NK cells, while other mechanisms such as oxidative stress, apoptosis, and angiogenesis are also involved.
This study: Preclinical studies on ginseng have indicated a number of immunologically relevant biological activities, including activation of macrophages, increases in NK cell activity and lymphocyte proliferation.
BIOBRAN MGN-3, a food supplement
Study: There is sufficient evidence suggesting MGN-3 to be an effective immunomodulator that can complement conventional cancer treatment.
Study: Our data show that MGN-3/Biobran upregulates NK cell activation markers, stimulates NK cell cytotoxic activity against neuroblastoma in vitro and in vivo and selectively augments the expansion of NK cells.
Study: These results suggest that MGN-3 is a potent natural adjuvant that efficiently activates DCs [dendric cells] and may therefore be useful for mounting an efficient immune response against infections and cancer.
Milk Vetch (Astragalus)
Milk vetch (Astragalus mongholicus) is a medicinal herb.
This study says Milk Vetch displayed its ability to control t-helper cells 1 and 2, essentially regulating the body’s immune responses.
This study concluded: This double-blind, placebo-controlled pilot study demonstrates that Echinacea, Astragalus and Glycyrrhiza herbal tinctures ingested by human subjects stimulate activation and proliferation of various immune cells. A tincture that combines these three herbs demonstrates an additive effect on activation, but no additional increase of proliferation.
Modified Citrus Pectin (dietary supplement)
…acids in MCP may stimulate the immune system through the activation of natural killer cells, cytotoxic T-cells, and B-cells. National Cancer Institute
This 2020 laboratory study looked at the effects of MCP on triple negative breast cancer cells. It found that MCP slowed and reduced migration, confirming its antimetastatic potential which may vary depending on the modification applied.
Study: The data demonstrates that MCP is a substance with strong immunostimulatory properties in human blood samples, including the activation of functional NK cells against K562 leukemic cells in culture.
Noni (Morinda citrifolia)
Study: The results of this study confirm the cellular and humoral immunostimulant properties of M. citrifolia fruits and justify its usage in traditional medicine.
This Review says: Thus it was later concluded that the Noni juice seems to suppress tumor growth indirectly by stimulating the immune system.
Study:These results suggest that noni modulates the immune system via activating of the CB2 receptors, and suppressing of the IL-4, but increasing the production of IFN- cytokines.
Study: These data demonstrate that fNE [fermented Noni exudate] appears to be able to stimulate the innate immune system and the adaptive immune system to reject tumor cells. NK cells respond quickly and appear to be among the major players of the innate immune system, while the adaptive immune system reacts later with a retained memory.
Probiotics
Probiotics, the friendly microflora in our bodies, contribute to the production of useful metabolites with positive effects on the immune system against various diseases such as cancer [Study]
This study found that probiotics C. butyricum and B. subtilis inhibited the proliferation of colorectal cancer cells, …and improved immune homeostasis.
Probiotic sources include sauerkraut, yogurt, kefir, kimchi, tempeh, miso, natto and kombucha.
If you are undergoing treatment, talk to your doctor before taking probiotics because they can be dangerous if you have a severely weakened immune system,
Polysaccharide-K
Polysaccharide-K (PSK) or Krestin, from the mushroom T. versicolor, is an approved mushroom product used for cancer treatment in Japan.
This study says: PSK is currently used as an immunothenapeutic agent for gastric, colorectal, and lung cancers in Japan. It has virtually no adverse effects, and it can be administered over a long term.
This Review of lung cancer studies says: Fifteen of 17 preclinical studies supported anticancer effects for PSK through immunomodulation and potentiation of immune surveillance, as well as through direct tumor inhibiting actions in vivo that resulted in reduced tumor growth and antimetastatic effects.
This study says: Several randomized clinical trials have demonstrated that PSK has great potential as an adjuvant cancer therapy agent, with positive results seen in the adjuvant treatment of gastric, esophageal, colorectal, breast and lung cancers.
Selenium and Zinc
This study says: Of all the nutrients involved in immunocompetence, selenium and zinc are the two trace elements that have been most frequently investigated in older adults. Selenium’s role in immune function, as well as cancer prevention, is related to its physiologic requirement as an active component in various enzymes… Zinc’s role is attributed to a decline in both antibody and cell-mediated responses, both of which have been reversed by supplemental zinc at physiologic levels.
Vitamin D therapy
Why? Vitamin D is crucial to the working of your immune system
Sunlight. Safe exposure to sunlight for a few hours each day.
Vitamin D If you cannot get sunshine you’ll need to supplement.
Many experts including Professor Michael Holick of Boston Medical School and John Cannell, M.D., director of the nonprofit Vitamin D Council, recommends that adults take 5,000 IU daily.
Note: Chemo depletes Vitamin D levels so 10,000 IUs daily is recommended for cancer patients – ask your doctor first. – study.
Wheat Grass
Wheatgrass is a food made from the Triticum aestivum plant. It’s regarded as a super potent health food with amazing benefits.
The authors of this study said their results demonstrated that wheatgrass-activated immune cells played a central role in building immunity…Several papers have indicated that wheatgrass has anti-tumor activities…
Other Ways to Boost Your Immune System
Mild Full Body Hyperthermia
Hyperthermia is the use of heat as a treatment for cancer.
This study noted: The use of hyperthermia as an adjunct to cancer immunotherapy is supported by an increasing number of research data. Both preclinical and clinical data results have demonstrated improved antitumor immune responses with the addition of mild hyperthermia.
Low Dose Naltrexone (a prescription medication)
Study: Evidence suggests that naltrexone, when used in low dose (1.75-4.5mg), shows inhibitory properties at the opioid receptors enabling the body to increase the production of endogenous opioids (endorphins) along with upregulating the immune system.
This (study) says: Although not a proven cure, evidence from clinical trials supports LDN as being a valuable adjunct for disorders in which the immune system plays a centralized role. Additionally, clinical trials have proposed a unique mechanism(s) allowing LDN to affect tumors including non-small cell lung cancer (NSCLC) at the cellular level by augmenting the immune system.
Ultraviolet Blood Irridation
Ultraviolet Blood Irradiation is the observation that controlled ultraviolet energy exposure promotes the maturation of dendritic cells through oxidative stimulation.This effect is similar to that of the oxygen/ozone action, and is very important as the immune system’s dendritic cell fraction plays a key role in the fight against cancer. Other cells of the immune system are activated as well, along with the enhanced production of cytokines, such as IL-2, tumor necrosis factor and interferon. Read more at www.issels.com
Page last updated January 2026
