P53 tumor suppressor protein

Restore p53

p53 keeps cancer in check
The role of p53 as a tumour suppressor is generally attributed to its ability to stop the proliferation of precancerous cells by inducing cell-cycle arrest or apoptosis – Study

Faulty p53 common in breast cancer
Somatic TP53 mutations are frequent in advanced stage or in cancer subtypes such as triple negative or HER2-amplified breast cancers
– Study

p53 function is inhibited by high levels of MDM2
In human cancers, the normal p53 function is inhibited by high levels of MDM2, leading to downregulation of tumor suppressive p53 pathways – Study

Even partial p53 recovery helps
Preclinical evidence demonstrates that regaining even partial p53 function can induce cancer regression – study

No drugs approved to repair p53
Somatic TP53 mutations have no clinically-available targeted therapies
– 2026 study

Drugs and products that may help correct restore p53 deficiency:

Curcumin treatment restores the expression of p53 – study
Niclosamide selectively kills p53-deficient cells – Study
Ivermectin can enhance p53 expression – Study
IP-6 up-regulates the expression of the p53 – Study
Hydroxytyrosol, (from olives) increases the expression of P53 – Study
Iodine increases the expression of P53 – Study
Mediterranean diet + coenzyme Q10 restores p53- Study
Berberine, Genistein, Apigenin, Triptolide, and Turmeric
target MDM2, p53 or the p53-MDM2 pathway, and many of these are under development as cancer chemopreventive and chemotherapeutic agents – Study
CAPE (from honeybee propolis), Fucoxanthin (from brown sea weeds), Wi-A and Wi-N (from Ashwagandha)have been shown to restore natural p53 activity in cancer cells – Study
Cruciferous vegetables derivative Phenethyl isothiocyanate can reactivate p53 – Study