Source: The website of the National Cancer Institute (http://www.cancer.gov)
Ipilimumab is approved to treat:
- Colorectal cancer in adults and children 12 years and older. It is used with nivolumab to treat metastatic microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) cancer that got worse after treatment with a fluoropyrimidine, oxaliplatin, and irinotecan.
- It is used as adjuvant therapy in patients with melanoma in the skin and lymph nodes who have already had surgery.
- It is used in adults and children 12 years and older whose disease cannot be removed by surgery or has metastasized (spread to other parts of the body).
- Renal cell carcinoma (a type of kidney cancer) that is advanced. It is used with nivolumab in some patients with renal cell carcinoma that has not been treated.
Ipilimumab is also being studied in the treatment of other types of cancer.
This study says: The median overall survival in the ipilimumab + gp100 arm was 10.0 months compared with 6.4 months in the gp100 arm…
The prescribing information for ipilimumab includes a boxed warning regarding the potential for severe and fatal immune-mediated adverse reactions resulting from T-cell activation and proliferation. These reactions may involve any organ system; however…
Ipilimumab injection may cause severe or life-threatening side effects. This includes inflammation of the intestine, which may cause tears in its walls; inflammation of the liver, which may cause severe liver damage; inflammation of the skin, which may cause a serious skin reaction; inflammation of the nerves, which may cause paralysis (loss of ability to move all or part of the body); inflammation of certain glands, which may affect how the glands work; or inflammation of the eyes.You may develop these symptoms during your treatment or during the first few weeks or months after you finish your treatment.
Why is this medication prescribed?
Ipilimumab injection is used to treat melanoma (a type of skin cancer) that cannot be treated with surgery or that has spread to other parts of the body. Ipilimumab injection is in a class of medications called monoclonal antibodies. It works by helping the body to slow or stop the growth of cancer cells.
Published Clinical Trials / Studies / Reviews
Improved Survival with Ipilimumab in Patients with Metastatic Melanoma