Jane McLelland Off Label Drugs for Cancer

Jane McLelland Off Label Drugs for Cancer

Metabolic Phenotype Tests

Metabolic Phenotype tests can provide valuable information about what is fuelling your cancer.

These fuel lines or metabolic pathways can then be targeted with therapies to limit or cut off the supply of crucial nutrients to the cancer cells in order to induce cell death.

For example, this study says breast cancer cells rely on the specific metabolic pathways in order to sustain their growth. Triple negative breast cancer (TNBC), an aggressive breast cancer subtype relies mainly on glycolysis (using glucose for cellular fuel), while estrogen receptor positive (ER+) breast cancer cells possess higher levels of OXPHOS which produces cellular energy in the form of ATP.

This study says the recent surge of interest in understanding cancer metabolism has identified several alternative fuels that tumor cells can utilize to support their metabolic needs. The dependence of tumors on these fuels reveals their unexpected metabolic flexibility to utilize a wide variety of alternative fuels.

However, this study cautions that the drawbacks of using metabolic-based therapies (e.g inhibiting glycolysis) is that they often cause non-specific toxicity to normal healthy tissues and cells. These anticancer therapies may target cells of the immune system which will reduce the immune response towards the tumor. Toxicity is also exhibited in neuronal [nerve] cells as reducing glucose levels can cause neuropathies as neurons are very energy intensive, requiring large amounts of glucose. 

This Scientific Review says: We now know that cancers harbor significant genetic heterogeneity, even within a single patient. Based on this heterogeneity, cancers routinely evolve resistance to treatment through switching from one growth pathway to another… Some effort is now being made in combining targeted agents so that more than one pathway can be affected, but lack of therapeutic success, significant toxicity and costs make this a challenge.

Cancer metabolism at a glance

Source: Journal of Cell Science
Cancer cells typically proliferate from one aberrant cell to more than 109 cells (the average number of cells in a tumor of ∼1 cm in diameter). To achieve and sustain that proliferative capacity, cancer cells must activate or enhance metabolic pathways (Lunt and Vander Heiden, 2011). These pathways use available nutrients to…to satisfy the energy demand for cell maintenance


Glucose and glutamine are critical nutrients indispensable for cancer cell growth. Li Wang, Jing-jing Li, et al

Jane McLelland – How to starve cancer

Jane McLelland was first diagnosed with cervical cancer and then  developed leukemia after chemotherapy treatment and was deemed Stage 4, Grade 4 in 1999. She beat her cancer by using a mixture of diet, exercise, supplements, herbs and off-label drugs to block the metabolic pathways that fuelled her cancer. Many others are now following her example. The protocols she used can be found in her book How to Starve Cancer.
Learn more at her website howtostarvecancer.com and Facebook page

Care Oncology Clinic (UK)

Using protocols similar to those used by Jane McLelland, The Care Oncology Clinic (a leading London cancer clinic) is undertaking a study and providing treatments that include off-label drugs. 

See also: Care Oncology Clinic (USA)


Following are four of the main targets of Jane McLelland’s approach to starving cancer. Find out possible interactions between drugs and supplements here and an online drugs checker like this one.
NOTE: Some of the drugs and supplements in these protocols can interact resulting in serious side effects. They should only be taken under the supervision of your doctor.

Metabolic Pathways

What are metabolic pathways?
Metabolic pathways are the fuel lines cancer cell uses to grow and spread!

Metabolic Pathways (Fuel lines)Treatment
GLUCOSE 
GLUT 1

 

STATIN (ATORVASTATIN)
QUERCETIN
INSULIN

 

LOW GLYCAEMIC DIET
EXERCISE 
METFORMIN       
BERBERINE
CHROMIUM PICOLINATE
PP PATHWAYDHEA
OXPHOSBERBERINE        
DOXYCYLINE
METFORMIN
NICLOSAMIDE
AEROBIC GLYCOLYSIS
VITAMIN C IV               2-DEOXYGLUCOSE (2DG)
DICHLOROACETATE (DCA)        BROMOPYRUVATE (3BP)
GLUTAMINE 
IGF-1METFORMIN
TAMOXIFEN
GLN OXPHOS

 

BERBERINE
DOXYCYCLINE
METFORMIN
NICLOSAMIDE
MTORMETFORMIN
BERBERINE
MACROPINOCYTOSISCHLOROQUINE
NUCLEOSIDE SALVAGEDIPYRIDAMOLE
GLUTAMINOLYSISEGCG
URSOLIC ACID
RESVERATROL
CURCUMIN
ASPARAGINASE
BPTES
FATTY ACIDS   
SREBP-1BEBERINE
ACETATEBEBERINE
ACLYHYDROXYCITRATE
F.A.S.METFORMIN + ASPIRIN
F.A.ODOXYCYCLINE
MILDRONATE
MEVOLONATESTATIN (ATORVASTATIN)
SREBP-2DIPYRIDAMOLE

Abnormal Cell Signalling

Abnormal Cell Signalling Treatment
Hedgehog Signalling
Common in MOST cancers
Berberine
Metformin
Mebendazole
Wnt/beta-catenin
Common in viral induced cancers
Aspirin
Dipridymole
Niclosamide
NSAIDS
Vitamin D3
Notch
Common in gastric, head & neck, cervical squamous, breast, colon, leukaemia, glioma and medulloblastoma cancers
Luteolin
Sulphoraphane
Quercetin
Niclosamide
TLR-4
Common in head & neck, gastric, colorectal, liver, pancreatic, skin, breast, ovarian and cervical cancers
Berberine
Low Dose Naltrexone (LDN)
TLR-9
Linked to oncogenic viruses
LDN
Chloroquine
Oestrogen Receptor
Common in breast, ovarian, endometrial. Other cancers maybe oestrogen positive such as gastric, NSCLC, colon and liver but this is less common and you would need to test to be sure
Indole-3-carbinol (I3C or DIM)
Melatonin
EGFR
Common in many cancers.
Berberine
Green Tea
Curcumin
Interleukin 1 and 6NSAIDS like Aspirin, Flarin, etodolac
NOTE: many NSAIDS come with the risk of gastric bleeds.
PPAR gammaStatins
Berberine
Honokiol
Ibuprofen
but improving gut flora is best strategy with probiotics, Omega 3, Vit A, D and Omega 7

Abnormal Growth Factors

Abnormal Growth FactorsTreatment
MMP-2Chitin
Mebendazole
Propranolol
MMP-3Glucosamine Sulphate
MMP-9Dipridymole
Doxycycline
Propranolol
VEGFAspirin
Propranolol
PDGFDipridymole
TGF-betaDipridymole
FGFBromelain
Citrus
Pectin

Fast Cell Division

Fast Cell DivisionComment
MebendazoleLow toxicity drug works same way as chemo. Add piperine to aid absorbtion
Intravenous Vitamin CActs like chemo drug. Lethal to stem cells. Add Doxycycline for greater effects.
Non- aspirin NSAIDsUse short term. Concurrent use of a statin and Dipyridamole mitigates cardio effects and enhances efficacy.
Berberine 
ChemotherapyLow dose is better than maximum tolerated dose which can kill you.
Metronomic low dose chemotherapyShown to boost anti-tumor T-cell immunity

Find out possible interactions between drugs and supplements here and an online drugs checker like this one.

Learn more at howtostarvecancer.com

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