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Sonodynamic and Photodynamic Therapy Combined

Sonodynamic and Photodynamic Therapy Combined

A combination of sonodynamic therapy (SDT) and photodynamic therapy (PDT), named sono-photodynamic therapy (S-PDT), is a new composite cancer therapy. Because the therapy can significantly improve the tumor curing effect, it has good application prospects in cancer prevention and treatment. Source: PubMed

Photodynamic therapyTreatment with drugs that become active when exposed to light.

Sonodynamic therapy (SDT)
Consists of the synergetic interaction between ultrasound and a chemical agent.

How is PDT used to treat cancer?

In the first step of PDT for cancer treatment, a photosensitizing agent is injected into the bloodstream. The agent is absorbed by cells all over the body but stays in cancer cells longer than it does in normal cells. Approximately 24 to 72 hours after injection, when most of the agent has left normal cells but remains in cancer cells, the tumor is exposed to light. The photosensitizer in the tumor absorbs the light and produces an active form of oxygen that destroys nearby cancer cells.

In addition to directly killing cancer cells, PDT appears to shrink or destroy tumors in two other ways. The photosensitizer can damage blood vessels in the tumor, thereby preventing the cancer from receiving necessary nutrients. PDT also may activate the immune system to attack the tumor cells.
Source: National Cancer Institute

Sono-Photo-Dynamic therapy

This study says:
Conclusions: These preliminary data suggest that SPDT has almost no toxicity, but may dramatically enhance the conventional therapeutic efficacy in advanced refractory esophagocadiac and gastric adenocarcinoma. SPDT has a good trend to be a new systemic, low toxicity tumor therapy and merit for further investigation.

This study says:
Sonodynamic followed by photodynamic therapy (SDT and PDT) can help to get a reasonable anti-tumor effect because the ultrasound can penetrate deeper into the cancer tissue compared with the laser light (635 nm).

This Review says:
Sono-PDT also blocks angiogenesis, the crucial conduit for cancer cell nutrition. Since the whole body is exposed to the light, all cancer or pre-cancerous cells within a range are affected, allowing the destruction and inhibition of cancer anywhere in the body. This treatment is entirely safe and the only side-effects are related to the destruction of the tumor cells that produce an inflammatory response intended at clearing the dead tumor tissue.

Photo-Dynamic therapy

This study states: Clinical studies revealed that PDT can be curative particularly in early-stage tumors. It can prolong survival in inoperable cancers and significantly improve quality of life. Minimal normal tissue toxicity, negligible systemic effects, greatly reduced long-term morbidity, lack of intrinsic or acquired resistance mechanisms, and excellent cosmetic as well as organ function-sparing effects of this treatment make it a valuable therapeutic option for combination treatments. With a number of recent technological improvements, PDT has the potential to become integrated into the mainstream of cancer treatment.

Sonodynamic Therapy

Sonodynamic therapy (SDT) has emerged as a promising option for the minimally invasive treatment of solid cancerous tumours. SDT requires the combination of three distinct components: a sensitising drug, ultrasound, and molecular oxygen.

This study states: Sonodynamic therapy (SDT) represents an emerging approach that offers the possibility of non-invasively eradicating solid tumors in a site-directed manner. It involves the sensitization of target tissues with a non-toxic sensitizing chemical agent and subsequent exposure of the sensitized tissues to relatively low-intensity ultrasound. Essentially, both aspects (the sensitization and ultrasound exposure) are harmless, and cytotoxic events occur when both are combined.

This study states: The major advantage of SDT over its close relative photodynamic therapy (PDT), is the increased penetration of ultrasound through mammalian tissue compared to light. As a result, SDT can be used to treat a wider array of deeper and less accessible tumours than PDT.

This study states: Theoretically, SDT using low-intensity ultrasound in combination with a sonosensitizer might be effective in all types of cancer without a need for choosing the target molecules, proteins and/or genes. Recent reports performed in both in vivo and in vitro studies support this hypothesis, and thus, SDT is a promising candidate for non-invasive and repeatable cancer therapy.

Photodynamic therapy is available in Ireland at the following. This list may be incomplete.

Phone    00 353 18 032000

Phone    00 353 1 277 4000

Beaumont Hospital, Beaumont Road, Dublin 9
Phone    00 353 18 093000

Centre for Restorative Dermatology
Dr. Rosemary Coleman
Blackrock Clinic
Dublin, Ireland
Tel: +353 (0)1 288 5333/2

Phone    00 353 61 301111

Kerry Skin Clinic
The Ashe Street Clinic
36 Ashe Street
Co. Kerry
Telephone 066 7125611

Belfast Skin Clinic
18 Deramore Drive, Belfast, BT9 5JQ
Tel: 028 9066 7077

1. Some cancer therapies can conflict with others. Do not start ANY therapy without consulting your doctor to ensure it’s safe and beneficial to do so.
2. Just because any given therapy worked for someone else does not necessarily mean it will work for you.
3. Although there are many viable alternative cancer treatments, there isn’t a “best” treatment for a certain type or stage of cancer.

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